7 edition of Ceramide Signaling found in the catalog.
February 1, 2003
Written in English
Molecular Biology Intelligence Unit
|The Physical Object|
|Number of Pages||170|
Exciting advances have been made regarding the roles of ceramide and its signaling in lung cancer in the past few years. Excess ceramide clearly has a critical function in inducing cell death in lung cancer cells, although those that escape this verdict are more prone to metastasis, as one important study by: 2. Ceramide NP is composed of a phytosphingosine base and stearic acid, a saturated fatty acid. It accounts for approximately % of the total ceramide pool in the stratum corneum (the uppermost layer of skin). Ceramide NP may also be referred to as Ceramide 3, which is based on the original INCI nomenclature. Topical application of Ceramide NP.
Furthermore, ceramide-enriched membrane domains mediate the assembling of the receptor with intracellular signaling molecules, in particular FADD, caspase 8, and the potassium channel Kvl.3 that finally mediate apoptosis initiated by CD95 : Volker Teichgräber, Gabriele Hessler, Erich Gulbins. This book attempts to analyze the latest discoveries in sphingolipid biology and how the alteration of their metabolism leads to altered signaling events and to the development of pathobiological disorders, such as cancer, cardiovascular diseases, asthma, diabetes, inflammation and infectious.
AICAR inhibits ceramide biosynthesis in skeletal muscle. Integrative Biology of Exercise. Westminster, CO. Bikman BT. Dihydroceramide desaturase inhibition prevents ceramide accumulation and improves insulin sensitivity. FASEB Summer Conference - Glucose Transporters, Signaling, and Diabetes. Keystone Colorado. Bikman BT. Thus our data suggest that crocin combats the serum/glucose deprivationinduced ceramide formation in PC cells by increasing GSH levels and prevents the activation of JNK pathway, which is reported to have a role of the signaling cascade downstream ceramide for neuronal cell : Takashi Ochiai, Shinji Soeda, Shigekazu Ohno, Hiroshi Shimeno, Hiroyuki Tanaka, Yukihiro Shoyama, Jo.
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Finally, the book closes with a section on the therapeutic implications of ceramide action, in the areas of cannabinoid action, chemotherapy, and atherosclerosis, and illustrates the potential medical significance of delineating the roles of ceramide in cell : Hardcover.
Little is known on the ceramide signaling governed by the salvage pathway, whereas the other pathways have been better investigated.
In this section, results from recent studies that begin to demonstrate roles for the salvage pathway in cellular responses are summarized (Fig. / Rick T. Dobrowsky --Ceramide signaling in cannabinoid action / Ismael Galve-Roperh [and others] --Ceramide glycosylation and chemotherapy resistance / Myles C.
Cabot --Ceramide in serum lipoproteins: function and regulation of metabolism / Mariana N. Nikolova-Karakashian --Therapeutic implications of ceramide-regulated signaling cascades. Ceramide & its derivatives: from metabolism to cell signaling. The structural core Ceramide Signaling book ceramide is the sphingoid base sphingosine (Figure 1), a lipid that is synthesized from the amino acid serine and the activated fatty acid palmitoyl-CoA (Figure 2).Sphingosine (or sphingenine) was first isolated and characterized by the German pathologist and ‘father of neurochemistry’ Johann Ludwig Cited by: Ceramide plays an important role in signal transduction in programmed cell death (apoptosis), the cell cycle, and cell differentiation and senescence.
Ceramide is the core molecule of sphingolipids. Ceramide links with other molecules to yield derivatives, such as sulfatides, globosides, glucosylceramide, sphingomyelin, and gangliosides.
The sphingomyelin pathway is a ubiquitous, evolutionarily conserved signaling system initiated by hyprolysis of the plasma membrane phospholipid sphingomyelin to generate ceramide. Ceramide acts as a second messenger in activating the Ceramide Signaling book cascade. Diverse cytokine receptors and environmental stresses utilize ceramide to signal by: Ceramide Signaling.
Editors: Futerman, Anthony H. (Ed.) Buy this book Hardcover ,99 € price for Spain (gross) Buy Hardcover ISBN ; Free shipping for individuals worldwide; Immediate ebook access* with your print order; Usually dispatched within 3 to 5 business days.
Lipid signaling, broadly defined, refers to any biological signaling event involving a lipid messenger that binds a protein target, such as a receptor, kinase or phosphatase, which in turn mediate the effects of these lipids on specific cellular signaling is thought to be qualitatively different from other classical signaling paradigms (such as monoamine neurotransmission.
Ceramide Signaling by Anthony H. Futerman,available at Book Depository with free delivery : Anthony H. Futerman. membranes and cell signaling Download membranes and cell signaling or read online books in PDF, EPUB, Tuebl, and Mobi Format.
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Ceramide-orchestrated signaling in cancer cells Article Literature Review (PDF Available) in Nature Reviews Cancer 13(1) December with 1, Reads How we measure 'reads'.
A ceramide is a lipid molecule, which are naturally occurring molecules such as sterols and fats. Lipid’s have one of three functions -- they make up part of the structure of a cell’s membrane, storing energy or signaling actions in cells.
Ceramide is a structural and signaling molecule. It is made up of a fatty acid called sphingosine and. Ceramide signaling can act as a lipid second messenger or as a mediator of various cellular signaling pathways by promoting receptor clustering.
The pathway plays important roles in apoptosis. (Pathway Ontology, PW_). Our pilot study has demonstrated the activation of ceramide generation in cancer cells upon folate withdrawal or methotrexate treatment as a pro-death stimulus.
Specifically, we have identified CerS6 and Cceramide as transmitters of folate status into cellular responses through ceramide signaling. the conservation of signaling mechanisms in eukaryotic cells, and offer an alternative approach to dissecting this novel signaling pathway.
Results Yeast CAPP is a PP2A species As a means of developing a model system for evaluating ceramide-mediating signaling in eukaryotes, we have ex. T1 - Ceramide and sphingosinephosphate signaling in embryonic stem cell differentiation. AU - Bieberich, Erhard. PY - /5/8. Y1 - /5/8. N2 - Recent studies show that bioactive lipids are important regulators for stem cell survival and by: 7.
Ceramide Signaling: Description: Ceramide is the second messenger that can be generated either by hydrolysis of SM through SM-specific PLC termed SMases or by de novo synthesis through the enzyme Ceramide Synthase. There are two classes of SMase,acidic (A-Smase) and neutral (N-Smase).
Ceramide/sphingomyelin and ceramide/sphingosinephosphate-interdependent cell-signaling pathways are significant for the regulation of cell polarity, apoptosis and/or proliferation, and as novel Author: Erhard Bieberich.
However, the mechanisms by which ceramide regulates apoptotic events are not fully defined. It is believed that the biological effect of ceramide depends on its concentration, the activation or differentiation status of the cell, and the time frame of action.
Here, we discuss the metabolism and cell apoptotic signaling of by:. Sphingolipids and their metabolic products, including ceramide, sphingosine, and sphingosinephosphate (S1P), 1 have emerged as important signaling molecules in a variety of biological processes ().Ceramide has been implicated as one of the components regulating apoptotic responses to stress, particularly those initiated by the mitochondria (1, 4, 5).Ceramide is a novel cellular second messenger which signals for apoptosis.
Several lines of evidence suggest an integral role of ceramide in photoreceptor apoptosis and cell death. Understanding their role in the pathogenic pathways of retinal degenerative diseases is important for development of Cited by: This review aims to provide updated information on the role of ceramide in the regulation of vascular tone.
Ceramide may induce vasodilator or vasoconstrictor effects by interacting with several signaling pathways in endothelial and smooth muscle cells. There is a clear, albeit complex, interaction between ceramide and redox by: 8.